兔抗GAB2(Phospho-Ser623)多克隆抗体

Background:

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Applications:

WB, IHC

Name of antibody:

GAB2(Phospho-Ser623)

Immunogen:

Peptide sequence around phosphorylation site of Serine 623(P-S-S(p)-P-S) derived from Human Gab2 .

Full name:

GRB2-associated binding protein 2

Synonyms：

GAB2

SwissProt:

Q9UQC2

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

74 kDa

WB Positive control:

293 cells, Hela cells and HepG2 cells lysates

WB Recommended dilution:

500-1000