兔抗GRM23多克隆抗体

Background:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities

Applications:

WB, IHC

Name of antibody:

GRM2/3

Immunogen:

Synthesized peptide derived from human GluR2/3.

Full name:

glutamate receptor, metabotropic 2/3

Synonyms：

GLUR2; mGlu2; GPRC1B; MGLUR2/GLUR3; mGlu3; GPRC1C; MGLUR3

SwissProt:

Q14832

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

99 kDa

WB Positive control:

Mouse brain tissue lysate

WB Recommended dilution:

500-3000