兔抗ITGB4(Phospho-Tyr1510)多克隆抗体

Background:

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.

Applications:

WB, IHC

Name of antibody:

ITGB4(Phospho-Tyr1510)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine1510(R-D-Y(p)-S-T) derived from Human ITGB4 .

Full name:

integrin, beta 4

Synonyms：

CD104

SwissProt:

P16144

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

202 kDa

WB Positive control:

HepG2 cells lysates treated with Na2VO3

WB Recommended dilution:

500-1000