兔抗BRAF(Phospho-Thr599)多克隆抗体

Background:

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung.

Applications:

IHC

Name of antibody:

BRAF(Phospho-Thr599)

Immunogen:

Peptide sequence around phosphorylation site of threonine 599 (L-A-T(p)-V-K) derived from Human B-RAF.

Full name:

B-Raf proto-oncogene, serine/threonine kinase

Synonyms：

NS7; BRAF1; RAFB1; B-RAF1

SwissProt:

P15056

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100